Michael,
my fav non-sport sets would have to be Stargate Atlantis and Stargate Heroes, Dexter, Warehouse 13 and the Star Wars Galaxy series (though I do collect a lot of the now defunct inkworks releases). Depending on which releases you are keen on some of the older release box prices are pretty cheap and I did do a few boxes IOT get chase cards, pieceworks and auto's. Now I prolly won't open boxes on some of those older releases, smallville, the 4400, jericho, alias etc as I only need limited cards and those cards are cheaper to buy as singles off ebay.com
Whatever you decide, have fun with it.